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. 1997 Jan 6;185(1):31–42. doi: 10.1084/jem.185.1.31

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IL-12 induces IFN-γ production from TCR transgenic T cells at suboptimal levels of stimulation. Splenocytes from Ii+ mice were incubated in either the absence (0) or presence of increasing amounts of the LACK peptide epitope, in the absence (open symbols) or presence of increasing amounts of rIL-12 (filled symbols), as designated on the lower axis. Each well contained 2 × 10⁵ Ii + APCs and 2 × 10⁵ TCR transgenic lymph node T cells. After 48 h, supernatants were collected and assayed for IL-2 and IFN-γ by ELISA. Data points represent means and standard deviations from duplicate determinations, and are representative of three separate experiments.