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Histologic response to L. donovani infection in livers of wild-type C57BL/6 and CD40L−/− mice. (A and B) Four weeks after infection, wild-type C57BL/6 mice (A) show formation of mature granulomas while CD40L-deficient mice (B) show no granuloma formation at parasitized foci (arrows). (C and D) At 8 weeks, granulomas have developed in CD40L-deficient mice but remain heavily parasitized (arrows). Panels A, B, and C, magnification of ×284; panel D, magnification of ×450.
