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. 2003 Nov;71(11):6453–6462. doi: 10.1128/IAI.71.11.6453-6462.2003

FIG. 9.

FIG. 9.

Treatment with anti-CD40 or anti-CTLA-4 enhances effect of antimony (Sb) in wild-type BALB/c mice. Liver parasite burdens were determined 12 days after infection, and mice were then injected once with either control rat or hamster IgG or suboptimal anti-CD40 (0.1 mg) or anti-CTLA-4 (0.3 mg). Mice either were not treated further or received low-dose Sb on day 14. Liver burdens on day 21 were compared to day 14 levels (1,202 ± 58 LDU; n = 12) to determine percent parasite killing. Results are from two to three experiments with 7 to 12 mice per group. P is <0.05 for results with both anti-CD40 plus Sb and anti-CTLA-4 plus Sb versus (i) day 14 LDU value for untreated mice and (ii) day 21 results with all other indicated treatments.