TABLE 1.

Leishmanicidal effects of anti-CD40 and anti-CTLA-4 treatments^a

Mouse group	Treatmentb			Liver parasite burden (LDU) on day:		% Killing
	IgG	Anti- CD40	Anti- CTLA-4	14	21
BALB/c
Wild type	+			1,087 ± 81	1,345 ± 99	0
		+			457 ± 56c	58
	+				1,833 ± 134	0
			+		500 ± 67c	52
IL-12p35−/−	+			1,703 ± 141	2,004 ± 179	0
		+			1,513 ± 164	11
	+				2,412 ± 201	0
			+		1,834 ± 146	0
C57BL/6
Wild-type	+			898 ± 96	1,024 ± 88	0
		+			341 ± 51c	62
	+				1,145 ± 141	0
			+		458 ± 64c	49
IFN-γ−/−	+			2,177 ± 199	2,954 ± 290	0
		+			3,152 ± 241	0
	+				2,896 ± 311	0
			+		2,579 ± 266	0
ICAM-1−/−	+			1,627 ± 182	1,828 ± 124	0
		+			748 ± 61c	54
	+				2,635 ± 288	0
			+		881 ± 99c	46
iNOS−/−	+			2,057 ± 202	2,391 ± 226	0
		+			894 ± 121c	56
	+				2,501 ± 183	0
			+		994 ± 79c	52
phox−/−	+			2,116 ± 158	2,201 ± 191	0
			+		773 ± 60c	63
	+				2,619 ± 246	0
			+		903 ± 100c	57

^aTwelve days after infection, mice received one injection of either 0.25 mg of rat IgG or anti-CD40 or 0.5 mg of hamster IgG or anti-CTLA-4, and LDU values were determined on day 21. Day 14 values indicate LDU values for untreated mice. Results shown are means ± SEM of results from two to three experiments with 7 to 10 mice per group.

^b+, mice received indicated treatment.

^cP, <0.05 versus day 14 value.