TABLE 2.

Response of CD40L knockout mice to chemotherapy^a

Mouse group	Treatment	Liver parasite burden (LDU) on day:		% Killing
		14	21
C57BL/6	None	1,168 ± 122	1,315 ± 92	0
	Sb		140 ± 37b	88
	AmB		91 ± 16b	92
CD40L−/−	None	1,785 ± 201	2,911 ± 270	0
	Sb		1,948 ± 194	0
	AmB		52 ± 33b	97

^aTwo weeks after infection (day 14), C57BL/6 wild-type and CD40L^−/− mice received no treatment, a single injection of 500 mg of Sb/kg, or three every-second-day injections of 5 mg of (AmB/kg). Results shown are means ± SEM of results from two experiments with six to seven mice per group.

^bP, <0.05 versus day 14 value.