Table 3.
Severity of Autoimmune Type Disorders Detected in Control and IL-4 tg Mice, Crossed with CTLA-4 tg Mice or Treated with Anti-IL-4 or Anti-CD4 Ab
| Anemia | Glomerulonephritis | Ig deposits in the kidneys | ||||
|---|---|---|---|---|---|---|
| Control mice | ||||||
| untreated | − | − | − | |||
| CTLA-4 tg mice | ||||||
| untreated | − | − | − | |||
| IL-4 tg mice | ||||||
| untreated | +++ | +++ | +++ | |||
| Control mice | ||||||
| anti-CD4 | ||||||
| treated | − | − | − | |||
| Control mice | ||||||
| anti-IL-4 | ||||||
| treated | − | − | − | |||
| Control mice × | ||||||
| CTLA-4 tg | ||||||
| crosses | − | − | − | |||
| IL-4 tg mice | ||||||
| anti-CD4 | ||||||
| treated | ++ | +++ | +++ | |||
| IL-4 tg | ||||||
| anti-IL-4 | ||||||
| treated | − | − | +/− | |||
| IL-4 tg × | ||||||
| CTLA-4 tg | ||||||
| crosses | +++ | +++ | +++ |
Summary of the autoimmune-type disorders detected in the IL-4 tg mice crossed with CTLA-4 tg mice or treated with anti-IL-4 or antiCD4 antibodies. The development of anemia, glomerulonephritis and Ig-depositions in the kidneys were determined for each individual mouse per group (for details of treatment and detection see Materials and Methods and Results). The severity of the disorder/group was scored as follows: undetectable (−), detectable (+), mild (++), severe (+++).