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. 1997 Jan 20;185(2):251–262. doi: 10.1084/jem.185.2.251

Figure 3.

Figure 3

Primary in vivo CTL response against influenza virus in WT mice (a), and mice with a targeted mutation of HSA (b), CD28 (c), or of both HSA and CD28 (d). Spleen cells were harvested from mice on day 7 after A/JAP-infection. The CTL activities were tested on either peptide (AA365-380 of the nucleoprotein from A/JAP virus)- pulsed (EL4-NP), or unpulsed EL4 cells (EL4). Representatives of three independent experiments using pooled spleen cells from 2–4 mice in each group are shown.