Figure 3.
Primary in vivo CTL response against influenza virus in WT mice (a), and mice with a targeted mutation of HSA (b), CD28 (c), or of both HSA and CD28 (d). Spleen cells were harvested from mice on day 7 after A/JAP-infection. The CTL activities were tested on either peptide (AA365-380 of the nucleoprotein from A/JAP virus)- pulsed (EL4-NP), or unpulsed EL4 cells (EL4). Representatives of three independent experiments using pooled spleen cells from 2–4 mice in each group are shown.
