Figure 4.
Antigen-induced corneal eosinophilia. Wild-type and eotaxin null mice received four subcutaneous immunizations with antigens from the parasitic helminth O. volvulus. Animals were subsequently injected intracorneally with parasite antigen and sacrificed 1 d later. 5-μm sections of the cornea were immunostained with rabbit sera to eosinophil major basic protein and eosinophils in the corneal stroma were counted. Data are shown as mean ± SEM for wild-type (n = 13) and eotaxin null (n = 14) mice with differences between groups being significant (P = 0.02).