Table 1.

Replication of Sequential Primary Isolates

Patient		Date		CD4 cells/mm3		Phenotype‡		p24 antigen*
								CCR2b		CCR3		CCR5		CXCR-4
										pg/ml
B		5/85		528		NSI		<30		<30		200		<30
		11/86		677		NSI		<30		<30		26,200		<30
		6/88		603		SI		<30		<30		29,500		400
		11/88		117		SI		<30		<30		33,320		7,820
C		5/84		1,233		NSI		<30		<30		1,024		<30
		1/85		1,038		NSI		<30		<30		72,400		<30
		2/86		1,049		SI		<30		<30		84,800		1,666
		7/86		485		SI		<30		<30		60,200		65,600
		12/86		346		SI		16,240		12,700		31,000		43,100
		5/87		141		SI		1,200		1,586		28,800		54,800
		6/88		186		SI		<30		<30		30,200		19,460
		11/89		38		SI		6,600		11,240		31,200		24,000
D		3/86		725		NSI		<30		<30		140		<30
		6/87		690		NSI		<30		<30		181		<30
		9/90		700		NSI		<30		<30		157		<30
		3/91		750		NSI		<30		<30		155		<30

^* HIV-1 p24 antigen was measured in culture supernatants on days 0, 4, 7, 10, and 14 after infection. Values represent the peak p24 levels measured on either day 10 or 14. A value of <30 pg/ml was considered negative.  

^‡ The SI phenotype for each isolate was determined using MT-2 cells as previously described (5, 29).