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. 1997 Mar 3;185(5):941–952. doi: 10.1084/jem.185.5.941

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D–Lc enhance both proliferation and differentiation of B cells activated with a soluble form of CD40L. A soluble form of CD40L (sCD40L) was expressed as a dimeric fusion protein between the mouse CD8α and the human CD40L. sCD40L was used as a supernatant of COS cells at a final concentration of 25% (right) to stimulate (A) B cell proliferation (10⁴ cells per well) and (B) B cell differentiation (10⁴ cells per well). IL-2 and IL-10 were added at concentration indicated in Materials and Methods. Results obtained with CD40L L cells are indicated for comparison (left). (results from 1 experiment representative of 3). No significant B cell proliferation and differentiation was observed in absence of CD40 engagement.