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. 1997 Mar 3;185(5):867–874. doi: 10.1084/jem.185.5.867

Figure 1.

Figure 1

Preliminary experiments to determine the course of visceral infection in five different populations of mice. (A) BALB/c mice not treated (•) or injected once with IL-4/anti–IL-4 complex one day before (day −1) L. donovani challenge (○). (B) BALB/c mice not treated (•) or injected with IL-4/anti–IL-4 starting on day −1 and twice per week for the first four weeks after challenge (○). (C) Control 129/Sv/Ev (•) and 129/Sv/PEP IL-4 transgenic mice (○). (D) BALB/c mice treated three times per week for 2 wk with normal sheep IgG (•) or sheep anti–IL-12 IgG (○) starting 2 h after challenge. (E) BALB/c mice challenged with 107 (•) or 2 × 107 (○) amastigotes. In mice challenged with 2 × 108 amastigotes, week 8 LDU were 761 ± 61 (n = 4 mice). Results in A–E indicate mean values (SE <16% in each case) from the single experiment performed with 4–5 mice per group. Note different vertical axis scale in B and C.