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. 1997 Mar 3;185(5):933–940. doi: 10.1084/jem.185.5.933

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Survival in vitro of NGF-dependent DRG neurons isolated from (a) mutant ICE^C285G transgenic and (b) ICE knockout newborn mice are protected from trophic factor withdrawal–mediated apoptosis. Survival represents the percentage of neurons remaining alive after 24 h of serum deprivation (100% at day 0). (a) The results are the average three double blindly scored independent experiments using newborn mice from lines 7512 and 7539. Neurons from each mouse were plated separately, and at least 400 neurons were counted per well. Results are expressed as means ± SEM. (b) Results are from an experiment double blindly scored performed in quadruplicate, from DRG neurons isolated from four wild-type and four ICE knockout newborn mice. At least 500 neurons were counted per well. Results are expressed as means ± SD.

Survival in vitro of NGF-dependent DRG neurons isolated from (a) mutant ICE^C285G transgenic and (b) ICE knockout newborn mice are protected from trophic factor withdrawal–mediated apoptosis. Survival represents the percentage of neurons remaining alive after 24 h of serum deprivation (100% at day 0). (a) The results are the average three double blindly scored independent experiments using newborn mice from lines 7512 and 7539. Neurons from each mouse were plated separately, and at least 400 neurons were counted per well. Results are expressed as means ± SEM. (b) Results are from an experiment double blindly scored performed in quadruplicate, from DRG neurons isolated from four wild-type and four ICE knockout newborn mice. At least 500 neurons were counted per well. Results are expressed as means ± SD.