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. 1997 Mar 3;185(5):833–842. doi: 10.1084/jem.185.5.833

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Recognition of naturally processed WT p53 epitopes by A2.1-restricted CTL. The responder CTL line and clone specific for WT p53.187-197 and derived from p53^−/− A2.1/K^b-Tg mice was (A) p53^−/− A2K^b 187 and (C) p53^−/− A2K^b 187 clone 4, respectively. The responder CTL line and clone specific for Hu WT p53.149-157 and derived from (p53^+/+) A2.1-Tg mice was (B) A2 149 and (D) A2 149 clone 5, respectively. CTL lines and clones were assayed for cytotoxicity against the following targets: EA2K^b (open circles), EA2K^b.1p53 transfectants (closed circles), untreated p53-deficient Saos-2 (open squares), Saos-2 pretreated with IFN-γ and TNF-α (closed squares), untreated Saos-2/143 p53-transfectants (open triangle), and Saos-2/143 pretreated with IFN-γ and TNF-α (closed triangles).