Table 2. Patterns of somatic mutations downstream of IgH J4 in Aag+/+ versus Aag-/- mice. Duplicated mutations are excluded in this data set. See legend to Table 1.
Mutation frequencies of this data set (duplicates excluded) for each experiment were calculated as the number of total mutations (point mutations plus insertions/deletions), divided by the number of basepairs sequenced in clones with mutations. Mutation frequencies for Aag+/+ were 0.95 × 10-2, 1.1 × 10-2, 2.2 × 10-2, 2.8 × 10-2; for Aag-/- : 2.9 × 10-2, 1.8 × 10-2, 2.1 × 10-2, 1.5 × 10-2 , for sets 1-4, respectively.
| Exp. | Duplicate mutations included | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| #1 | to | Aag+/+ | Total | Aag-/- | Total | |||||||
| from | A | C | G | T | 70 | A | C | G | T | 187 | ||
| A | 5 (7.1) | 16 (23) | 7 (10) | 28 (40) | A | 20 (12) | 31 (16) | 23 (11) | 74 (39) | |||
| C | 1 (1.4) | 4 (5.7) | 8 (11) | 13 (18) | C | 4 (2.1) | 3 (1.6) | 4 (2.1) | 11 (5.8) | |||
| G | 9 (13) | 5 (7) | 2 (2.9) | 16 (23) | G | 25 (13) | 10 (5.3) | 8 (4.3) | 43 (23) | |||
| T | 5 (7.1) | 4 (5.7) | 4 (5.7) | 13 (19) | T | 18 (9.6) | 26 (14) | 15 (8.0) | 59 (32) | |||
| #2 | A | C | G | T | 160 | A | C | G | T | 194 | ||
| A | 14 (8.7) | 29 (18) | 18 (11) | 61 (38) | A | 18 (9.3) | 21 (11) | 23 (12) | 62 (32) | |||
| C | 5 (3.1) | 5 (3.1) | 11 (6.8) | 21 (13) | C | 4 (2.1) | 6 (3.1) | 18 (9.3) | 28 (15) | |||
| G | 30 (19) | 8 (5.0) | 6 (3.7) | 44 (28) | G | 23 (12) | 18 (9.3) | 5 (2.6) | 46 (24) | |||
| T | 11 (6.8) | 13 (8.1) | 10 (6.2) | 34 (21) | T | 19 (9.8) | 28 (14) | 11 (5.7) | 58 (30) | |||
| #3 | A | C | G | T | 149 | A | C | G | T | 150 | ||
| A | 15 (10) | 23 (15) | 17 (11) | 55 (36) | A | 11 (7.7) | 33 (23) | 13 (9.1) | 57 (40) | |||
| C | 3 (2.0) | 2 (1.3) | 19 (13) | 24 (16) | C | 2 (1.4) | 5 (3.5) | 10 (7.0) | 17 (12) | |||
| G | 22 (15) | 7 (4.7) | 5 (3.4) | 34 (23) | G | 18 (13) | 6 (4.2) | 3 (2.1) | 27 (17) | |||
| T | 9 (6) | 17 (11) | 10 (6.7) | 36 (24) | T | 16 (11) | 17 (12) | 9 (6.3) | 42 (29) | |||
| #4 | A | C | G | T | 163 | A | C | G | T | 51 | ||
| A | 11 (6.7) | 32 (20) | 20 (12) | 63 (39) | A | 3 (5.7) | 9 (17) | 5 (9.4) | 17 (32) | |||
| C | 3 (1.8) | 5 (3.1) | 9 (5.5) | 17 (10) | C | 1 (1.9) | 2 (3.8) | 7 (13) | 10 (19) | |||
| G | 24 (15) | 8 (4.9) | 5 (3.1) | 37 (23) | G | 5 (9.4) | 2 (3.8) | 3 (5.7) | 10 (19) | |||
| T | 16 (9.8) | 16 (9.8) | 14 (8.6) | 46 (28) | T | 4 (7.5) | 7 (13) | 3 (5.7) | 14 (26) | |||