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. Author manuscript; available in PMC: 2009 Jan 15.
Published in final edited form as: Exp Cell Res. 2007 Sep 29;314(2):398–412. doi: 10.1016/j.yexcr.2007.09.015

Fig. 9.

Fig. 9

GSH increase contributes to HGF’s mitogenic effect in H4IIE cells plated under low cell density. Part A: H4IIE cells were plated at LD or HD at the time of HGF (10 ng/ml) treatment for up to 48 hours. DNA synthesis was measured by 3H-thymidine incorporation into DNA over the last 4 hours of the treatment or before the start of HGF treatment (time 0). *p<0.005 versus 0 hour, †p<0.05 versus 0 hour from 4 independent determinations. Part B: Increase in GSH under LD contributes to HGF’s mitogenic effect. H4IIE cells were plated under LD and treated with HGF (10 ng/ml), BSO (200 μM) or both BSO and HGF for 24 hours. DNA synthesis was measured as above. *p<0.005 vs. LD control, **p<0.05 vs. both HGF and BSO from 3 to 5 experiments.