Table 2.
Effects of freeze-dried BRBs on azoxymethane (AOM)-induced colon cancer in the F344 rat [41]
| Treatment | Tumor Multiplicitya-c (% inhibition) | Tumor Volumeb,d (mm3) | Tumor Burden b,e (% inhibition) |
|---|---|---|---|
| Control diet | 0 | NA | NA |
| 5.0% BRBs | 0 | NA | NA |
| AOM only | 2.3 ± 0.5 | 33.8 ± 7.7 | 120.9 ± 25 |
| 2.5% BRBs + AOM | 1.4 ± 0.3* (42) | 35.9 ± 17.8 | 87.5 ± 41.5 (28) |
| 5.0% BRBs + AOM | 1.3 ± 0.2* (45) | 42.4 ± 15.0 | 69.8 ± 22.5 (42) |
| 10.0% BRBs + AOM | 0.7 ± 0.2* (71) | 15.7 ± 5.0 | 30.2 ± 9.8 (75) |
a
Mean number of tumors per animal within a given treatment group (n=18).
b
Values are means ± SE.
c
*Significantly different from AOM only (p<0.05).
d
Calculated as follows: tumor length × width × height × π/6. Tumor volume means are calculated by summing tumor volumes within a group and dividing by the number of tumor-bearing animals in that treatment group. NA, not applicable.
e
Sum of tumor volumes for a tumor-bearing animal. Tumor burden means are calculated by summing tumor burdens within a group and dividing by the number of tumor-bearing animals in that treatment group.