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. 1997 Mar 17;185(6):1143–1148. doi: 10.1084/jem.185.6.1143

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Epinephrine enhances LPS-induced fibrinolytic activation, while not influencing inhibition of fibrinolysis. Mean (± SE) plasma concentrations of tPA antigen, PAP complexes, PAI-1 antigen, and activity after intravenous injection of LPS (2 ng/kg, lot EC-5) at t = 0. LPS = subjects injected with LPS only (n = 6); EPI-3 = subjects infused with epinephrine (30 ng/kg/min) from t =−3 h to 6 h (n = 5); EPI-24 = subjects infused with epinephrine (30 ng/kg/min) from t = −24 h to 6 h (n = 6). EPI-3 and EPI-24 enhanced LPS-induced increases in tPA and PAP complexes (P <0.05 versus LPS only), while not significantly changing PAI-1 antigen or activity.