Figure 2.

Leukocyte rolling flux in untreated animals (n = 3) and sensitized wild-type animals at 8 h after antigen challenge, before and after treatment with either an anti–α₄-integrin antibody (n = 5) or a nonbinding, isotype-matched control antibody (n = 3). At 8 h after antigen challenge, administration of an anti–α₄-integrin antibody reduced leukocyte rolling flux by ∼50%, whereas a nonbinding IgG had no effect. *P <0.05 relative to untreated value. ^† P <0.05 relative to respective Ag 8 h value.