Figure 1.

In contrast to IFN-γ ko and IL-12 p40−/− mice, iNOS ko animals survive acute infection with T. gondii (ME49). Mice were infected either by the i.p. (A) or p.o. (B) route of infection with 20 ME49 cysts. The data shown in A are pooled from three independent experiments and involve a minimum of 10 ko mice per group. The experiment presented in B involved five mice per group and is representative of three performed. As described in Materials and Methods, infected C57BL/6 × 129/J F1 and C57BL/6 animals displayed similar survival patterns (inset).