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. 1997 Apr 7;185(7):1307–1316. doi: 10.1084/jem.185.7.1307

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Response of arthritic Lewis rats to peptides containing the COOH-terminal determinants within Bhsp65 (A) or Rhsp65 (B). Arthritis was induced as described in Materials and Methods. 4 wk after the appearance of clinical AA, rats were killed and their spleen cells (SPC) tested in a proliferation assay. The results are expressed as cpm. The results of a representative experiment are shown here. Similar results were obtained in repeat experiments (data not shown). The amino acid sequences of the five peptides comprising the BCTD and of the corresponding Rhsp65 peptides are given in Table 2. Response to peptide 177–191 is shown as a positive control. Rhsp65 peptide 465–479 could not be tested in this series of experiments.