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. 1997 May 19;185(10):1725–1733. doi: 10.1084/jem.185.10.1725

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Physiological induction of a proliferative response to B5 during CIA. DBA/1LacJ mice were immunized with CII for the induction of CIA. 35 d later, splenic cells were assayed for proliferation in response to a concentration (7 μM) of different TCR peptides, B1 and B5. [³H]thymidine incorporation was measured by liquid scintillation counting. There was no significant response to B5 in nonimmunized mice, nor in mice challenged with HEL, 35 d after immunization. Individual responses of eight individual mice are shown.