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. 1997 Jun 2;185(11):1987–1995. doi: 10.1084/jem.185.11.1987

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Secretion of IL-12 p70 by monocytes is suppressed by incubation with heat-killed Histoplasma capsulatum (HC). Heat-killed HC at the indicated concentrations was incubated with human monocytes 2 h before stimulation with LPS (1 μg/ml) plus IFN-γ (1 μg/ml), SAC (0.01%) plus IFN-γ (1 μg/ ml), or CD40L trimer (3 μg/ml) plus IFN-γ (1 μg/ml) (A). (B) IL-10 and TNF-α levels from the same culture supernatants. Data are representative of five experiments, and percent suppression by HC was similar in all instances.