Figure 1.

TCR-γ/δ cells regulate HSV-1 infection. (A) TCR null mice were infected with HSV-1 in the hind footpad and were monitored for survival. TCR-β^+/−/δ^+/− mice, open triangles; TCR-β^+/−/δ^−/− mice, closed triangles; TCR-β^−/−/δ^+/− mice, open circles; and TCR-β^−/−/ δ^−/− mice, closed circles. All groups of mice contained at least three animals, and this plot is representative of two separate experiments. (B) TCR-α^−/− mice were infected with HSV-1 in the cornea and were monitored for survival. Control hamster Ig-treated TCR-α^−/− mice, closed circles; anti– TCR-γ/δ mAb–treated TCR-α^−/− mice, open circles. Both groups of mice contained five animals and this plot is representative of three separate experiments.