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. 1997 Jun 2;185(11):1997–2013. doi: 10.1084/jem.185.11.1997

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Model depicting the likely differential distribution of 9-Oacetylated sialoglycoconjugates between resting peripheral CD4 and CD8 T cells. Sialomucins are present on both CD8 and CD4 cells, but are only 9-O-acetylated in the latter. Cell surface sialomucin molecules usually have a rod like extended conformation and a high negative charge, and appears to prevent CHE-FcD access to O-acetylated glycolipids (gangliosides) that are much closer to the cell surface membrane. OSGPase recognizes sialylated clustered O-linked glycans and cleaves the adjacent polypeptide backbone, thus unmasking recognition of the enzyme-resistant O-acetylated gangliosides by the CHE-FcD probe.