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. 1997 Jun 16;185(12):2061–2068. doi: 10.1084/jem.185.12.2061

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Fusion of L. donovani–containing phagosomes with newly formed endosomes. J774 macrophages were infected with stationary-phase promastigotes for 60 min and further incubated for 60 min. Cells were then fed a 5- and 16-nm BSA–gold particles mixture for 30 min, followed by a chase period of 60 min, and processed for electron microscopy. (A) Phagosomes containing wild-type Leishmania (P) display low fusogenic properties with endocytic organelles (E). When fusion occurred, only few gold particles were observed in the phagosome (arrow). (B) Phagosomes containing the LPG-deficient C3PO mutant (P) were filled with large number of BSA– gold particles, indicating their acute ability to fuse with endosomes.