Figure 7.
The reexpression of MHC class I on NK targets expressing CD40 is able to inhibit NK3.3-mediated cytotoxicity. Percent lysis obtained by using effector NK3.3 cell line in the presence of untreated T2 cells (open circles), T2 preincubated with the anti-CD57 IgM mAb TIB200 (open triangles), with the anti-CD40 IgM mAb 14G7 (closed triangles). Closed circles indicate cytotoxicity obtained with T2/TAP1+2 targets. The results refer to one representative experiment out of four performed.