Table 2.

>The Size of Ly49-defined NK Cell Subsets Is Influenced by Ly49A Transgene and MHC

		MHC		Percentage of NK1.1+CD3− cells
				mAb JR9- 318 (Ly49A)		mAb SW5E6 (Ly49C/I)		mAb 4D11 (Ly49G)
Tg line  No. 2		β2m−/−		96.7 ± 2.3		64.8 ± 1.9		57.2 ± 6.6
		H-2b		98.0 ± 0.9		45.6 ± 5.0		38.5 ± 3.0*
		H-2d		93.8 ± 1.3		47.2 ± 2.8‡		18.5 ± 1.8 *
non-Tg LM		β2m−/−		31.8 ± 3.6		64.2 ± 1.3		63.5 ± 0.1
		H-2b		21.3 ± 3.4		48.4 ± 5.0		51.0 ± 3.9
		H-2d		15.5 ± 3.1		55.1 ± 0.7		50.7 ± 3.3
Tg line  No. 12		H-2b		90.2 ± 1.7		46.5 ± 4.5§		46.1 ± 3.1‡
		H-2b/d		89.6 ± 2.7		42.6 ± 3.2‡		22.3 ± 3.1 *
non-Tg LM		H-2b		24.5 ± 1.6		52.9 ± 1.9		54.7 ± 0.5
		H-2b/d		15.1 ± 3.4		49.2 ± 2.1		45.7 ± 4.4

Data represent means of three or more determinations ± SDs. The nontransgenic samples were littermates of the respective transgenics and were tested in parallel. Substantial effects of transgene expression on Ly49G2 usage are indicated in bold.  

^* P <0.001;  

^‡ P <0.01;  

^§ P <0.05, compared to nontransgenic mice of same MHC type by Student's t test.