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. 1996 Dec 1;184(6):2311–2326. doi: 10.1084/jem.184.6.2311

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Expression of TIMP-1 mRNA and localization of macrophages to injured sciatic nerve. (A) Longitudinal cryosection of 4-d postcrush nerve was hybridized with digoxigenin-labeled antisense RNA probe to TIMP-1. The proximal, crush, and distal segments of the injured nerve are indicated. The bracket indicates the crush site. The arrow points to the India ink at the crush site. TIMP-1 expression is seen at the crush site and in the distal segment of injured nerve. The distal segment of the section has a fragmented appearance and loss of some tissue because of poor adherence of nerve sections to the slide. (B) Immunohistochemical staining of macrophages in sections of injured nerve by means of a macrophage-specific antibody F4/80, and a horseradish peroxidase–labeled secondary antibody. Increased numbers of macrophages are seen at the crush site and in the distal segment. Bar, 100 μm.