Table 1.
mRNA Levels in Crush and Distal Segments of Sciatic Nerve at 4 D After Crush
| mRNA transcript | Crush segment | Distal segment | ||
|---|---|---|---|---|
| Fold induction | ||||
| TIMP-1 | 11.5 ± 3.0* | 9.6 ± 2.3* | ||
| Stromelysin-1 | 5.5 ± 1.8* | 5.0 ± 1.0* | ||
| Gelatinase B | 5.1 ± 1.2* | 3.2 ± 0.3* | ||
| GAPDH | 1.6 ± 0.2 | 1.2 ± 0.3 | ||
| CSF-1 | 1.7 ± 0.2 | 1.9 ± 0.2* | ||
| TGF-β1 | 4.1 ± 0.3* | 4.6 ± 0.7* | ||
| TNF-α | 1.6 ± 0.6 | 6.3 ± 1.1* | ||
| IL-1α | 6.2 ± 2.1* | 18.3 ± 6.7* | ||
| NGF-β | 3.9 ± 1.4* | 22.0 ± 4.0* | ||
| c-fms | 2.6 ± 0.4* | 2.2 ± 0.4* | ||
| p75NGFR | 2.9 ± 0.9* | 24.0 ± 6.2* | ||
RNA expression was monitored by RT-PCR and quantified as described in the legend to Fig. 2 B. Values represent fold induction, which is the ratio of mRNA in injured nerve to that in contralateral (control) nerve. Values represent the mean ± SD of the results of three experiments; those indicated by an asterisk (*) are significantly different from values in contralateral nerve (P <0.05, Student's t test).