Table III.
Inflammatory infiltrate in the wound bed of PPARα wild-type and null mice
| Day postwounding |
Neutrophil number |
Monocyte/macrophage number |
||
|---|---|---|---|---|
| PPARα+/+ | PPARα−/− | PPARα+/+ | PPARα−/− | |
| 1 | 76.1 ± 5.5 | 63.6 ± 2.5a | 12.4 ± 0.8 | 27.8 ± 3.1b |
| 3 | 50.3 ± 6.0 | 40.5 ± 3.4 | 51.2 ± 2.8 | 54.4 ± 2.1 |
| 5 | 16.1 ± 2.2 | 11.6 ± 1.0 | 50.0 ± 3.3 | 47.7 ± 2.5 |
The number of neutrophils and of monocytes/macrophages present in the wound bed at day 1, 3, and 5 postwounding was assessed based on morphological criteria in PPARα wild-type and null mice. The values represent the mean of the number of cells counted in five standardized microscope fields per section, performed on three different animals for each stage postwounding, ± SEM.
a
Based on a Student's t test, the difference is statistically significant (P < 0.05).
b
Based on a Student's t test, the difference is statistically significant (P < 0.01).