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. 2001 Jul 9;154(1):33–48. doi: 10.1083/jcb.200011069

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Copyright © 2001, The Rockefeller University Press

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Figure 5. — Arrays increase in size after hormone treatment and then later decrease. (a) Array size by GFP-GR versus time after hormone. Changes in array size were detected by GFP-GR as a function of time. Cells were treated with 100 nM dexamethasone at time 0 and then fixed in paraformaldehyde at the time points shown. At each time point, 100 cells containing arrays were randomly selected and then the arrays were classified into one of three size ranges. (b) Changes in array size detected by DNA FISH before hormone and 1.5 or 8 h after hormone. For each treatment, 100 cells were randomly selected and then the perimeter of the array in each cell was measured. Note that by 8 h after hormone treatment, arrays have recondensed to the prehormone state. (c) Times of array decondensation and recondensation by live cell analysis. Histogram plot showing times at which arrays showed the first significant signs of either decondensation or condensation. These data were obtained from 128 time-lapse movies of individual cells. On average, decondensation occurred before condensation. Of 22 movies that were long enough to capture both decondensation and condensation, 21 showed a single decondensation followed by a single recondensation (see text).