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(A) Schematic of feedback regulation of ctrA transcription during the cell cycle. Shaded areas in the cells indicate the presence of CtrA. The times of CtrA proteolysis and CtrA phosphorylation (13) are indicated. After threshold levels of CtrA≈P accumulate in the predivisional cell, the P1 promoter is repressed, and the P2 promoter is activated by CtrA≈P binding to recognition motifs in these promoters. (B) The regulatory network controlled by CtrA≈P.
