Table 3.
Geometric least square mean | Ratio (90% CI) | ||||
---|---|---|---|---|---|
Pharmacokinetic parameter | CAPD | APD | Normal renal function | CAPD | APD |
Cmax (ng ml−1) | 236.8 | 272.8 | 1144 | 0.21 (0.15, 0.29) | 0.24 (0.17, 0.34) |
AUC(0,24 h) (ng ml−1 h) | 3383 | 3596 | 4415 | 0.77 (0.59, 0.99) | 0.24 (0.17, 0.34) |
t1/2 (h) | 45.3 | 37.7 | 6.2 | 7.4 (5.8, 9.3) | 6.1 (4.8, 7.8) |
CL/F (l h−1) | 3.0 | 3.0 | 23.0 | 0.13 (0.1, 0.17) | 0.12 (0.1, 0.16) |
Cmin (ng ml−1) | 87.8 | 91.4 | 30.4 | 2.9 (2.09, 4) | 3.0 (2.2, 4.2) |