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. 2007 Jul 27;64(6):738–744. doi: 10.1111/j.1365-2125.2007.02963.x

Table 3.

Post hoc interstudy analysis of lamivudine pharmacokinetic differences between CAPD or APD and a reference comparator group of volunteers with normal renal function [1]

Geometric least square mean Ratio (90% CI)
Pharmacokinetic parameter CAPD APD Normal renal function CAPD APD
Cmax (ng ml−1) 236.8 272.8 1144 0.21 (0.15, 0.29) 0.24 (0.17, 0.34)
AUC(0,24 h) (ng ml−1 h) 3383 3596 4415 0.77 (0.59, 0.99) 0.24 (0.17, 0.34)
t1/2 (h) 45.3 37.7 6.2 7.4 (5.8, 9.3) 6.1 (4.8, 7.8)
CL/F (l h−1) 3.0 3.0 23.0 0.13 (0.1, 0.17) 0.12 (0.1, 0.16)
Cmin (ng ml−1) 87.8 91.4 30.4 2.9 (2.09, 4) 3.0 (2.2, 4.2)