Figure 1.

Observed ciclosporin concentrations (DV) vs. individual model predicted concentrations (IPRE) and population model predicted concentrations (PRED) with line of unity. Ciclosporin was given to 162 patients as an intravenous 4-h infusion (3 mg kg⁻¹) and a single oral dose (10 mg kg⁻¹) with an interval of at least 24 h between doses (usually 48–72 h). One patient was accidentally given only 1 mg kg⁻¹ of ciclosporin orally