Table 5.
Pharmacokinetic parameters of sirolimus (dose-normalized values)
| Visit | Values mean (95%CI) |
|---|---|
| Week 4 | |
| tmax (h)a (n = 15) | 1.25 (0.67–6.00) |
| Cmax (µg ml−1) (n = 15) | 62.4 (45.2, 79.7) |
| Cmin (µg ml−1) (n = 14) | 25.0 (18.9, 31.2) |
| AUC(0,12 h) (µg ml−1 h) (n = 14) | 835 (632, 1037) |
| Month 3 | |
| tmax (h)a (n = 13) | 2.00 (1.25–6.00) |
| Cmax (µg ml−1) (n = 13) | 85.7 (66.9, 105) |
| Cmin (µg ml−1) (n = 13) | 32.5 (22.8, 42.2) |
| AUC(0,12 h) (µg ml−1 h) (n = 13) | 1078 (870, 1285) |
| Month 6 | |
| tmax (h)a (n = 18) | 2.00 (0.67–4.00) |
| Cmax (µg ml−1) (n = 18) | 85.2 (62.5, 108) |
| Cmin (µg ml−1) (n = 17) | 31.8 (23.0, 40.8) |
| AUC(0,12 h) (µg ml−1 h) (n = 17) | 1100 (820, 1381) |
CI – Confidence interval;
a
tmax is reported as median value and observed range.