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. 2001 Mar 5;152(5):971–984. doi: 10.1083/jcb.152.5.971

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Activation of CDC42 by PYK2, but not FAK. (A) PYK2 activation of CDC42, but not Rac. (B) PYK2, but not FAK, activation of CDC42 requires PYK2 catalytic activity and its binding region to PSGAP. (A and B) HEK293 cells were transfected with indicated constructs. Cell lysates were incubated with GST-PBD immobilized on beads. Bound active CDC42 or Rac was resolved on SDS-PAGE and detected by immunoblotting. Equal amounts of small G proteins were expressed as indicated. The expression of PYK2 and FAK are also shown. (Solid arrows) Small G proteins; (open arrows) PYK2 or FAK.