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. 2001 Nov 12;155(4):637–648. doi: 10.1083/jcb.200105081

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Copyright © 2001, The Rockefeller University Press

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Figure 3. — S. aureus–induced caspase-3 activation is mediated by α-toxin. (A) DEVDase activity in extracts of Jurkat cells incubated for 4 h with the indicated supernatant dilutions of the various S. aureus strains. (B–D) DEVDase activity in extracts of Jurkat cells incubated for 4 h with the indicated concentrations of α-toxin (B), Wood 46 supernatant (SN) (C), or the agonistic anti-CD95 antibody (D) in the absence or presence of the neutralizing sheep anti– α-toxin antiserum (1:100). The dashed line (control) represents the DEVDase activity in untreated cells.

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