Table 5.
Population and family-based QTDT results for adult cohort for the most significant variants among CHRM2 gene
| Population-based | Family-based | ||||||||
| Position (bp) | Phenotype | NPOPULATION | χ2 | P | GE | NFAMILY | χ2 | P | GE |
| rs2350780 | PIQ | 359 | 0.26 | 0.610 | 0.47 (A) | 95 | 3.62 | 0.057 | 3.31 (A) |
| (136243509) | VIQ | 359 | 0.01 | 0.920 | 0.12 (A) | 95 | 0.62 | 0.431 | 1.26 (A) |
| FSIQ | 359 | 0.05 | 0.823 | 0.22 (A) | 95 | 1.98 | 0.159 | 2.22 (A) | |
| rs1364409 | PIQ | 350 | 0.15 | 0.699 | 0.35 (A) | 92 | 4.90 | 0.027 | 3.13 (A) |
| (136262573) | VIQ | 350 | 0.05 | 0.823 | 0.24 (A) | 92 | 0.02 | 0.888 | 1.05 (A) |
| FSIQ | 350 | 0.05 | 0.823 | 0.22 (A) | 92 | 1.25 | 0.264 | 0.72 (A) | |
| rs7782965 | PIQ | 345 | 0.94 | 0.332 | 0.93 (C) | 91 | 5.29 | 0.021 | 3.36 (C) |
| (136274673) | VIQ | 345 | 0.24 | 0.624 | 0.49 (C) | 91 | 0.33 | 0.566 | 0.16 (C) |
| FSIQ | 345 | 0.43 | 0.512 | 0.67 (C) | 91 | 2.08 | 0.149 | 1.60 (C) | |
| rs1378646 | PIQ | 363 | 1.08* | 0.303 | 1.05 (A) | 90 | 6.48 | 0.011 | 3.77 (A) |
| (136214872) | VIQ | 363 | 0.61 | 0.435 | 0.73 (A) | 90 | 1.27 | 0.26 | 1.10 (A) |
| FSIQ | 363 | 0.76 | 0.383 | 0.78 (A) | 90 | 3.65 | 0.056 | 2.36 (A) | |
| rs2061174 | PIQ | 389 | 4.64* | 0.031 | 2.10 (A) | 101 | 9.14 | 0.003 | 6.89 (A) |
| (136311940) | VIQ | 389 | 0.06 | 0.806 | 0.24 (A) | 101 | 0.01 | 0.920 | 1.78 (A) |
| FSIQ | 389 | 0.97 | 0.325 | 0.89 (A) | 101 | 1.82 | 0.177 | 3.76 (A) | |
| rs17411561 | PIQ | 306 | 0.15 | 0.699 | 0.47 (T) | 79 | 1.28 | 0.589 | 0.69 (C) |
| (136332728) | VIQ | 306 | 0.42 | 0.517 | 0.24 (T) | 79 | 0.15 | 0.699 | 0.44 (T) |
| FSIQ | 306 | 0.02 | 0.888 | 0.11 (T) | 79 | 0.60 | 0.439 | 0.08 (C) | |
| rs324640 | PIQ | 386 | 2.37 | 0.124 | 1.40 (A) | 123 | 2.36 | 0.126 | 3.05 (A) |
| (136339536) | VIQ | 386 | 0.02 | 0.888 | 0.12 (A) | 123 | 0.21 | 0.647 | 1.57 (A) |
| FSIQ | 386 | 0.54 | 0.462 | 0.67 (A) | 123 | 1.04 | 0.308 | 2.22 (A) | |
| rs324650 | PIQ | 369 | 2.09 | 0.148 | 1.28 (A) | 117 | 2.69 | 0.101 | 1.69 (T) |
| (136344201) | VIQ | 369 | 0.15 | 0.699 | 0.36 (A) | 117 | 0.00 | 1.000 | 0.78 (T) |
| FSIQ | 369 | 0.13 | 0.718 | 0.33 (T) | 117 | 0.58 | 0.446 | 0.77 (T) | |
*Stratification significant at P = 0.05
Note: N denotes the number of individuals informative for the within family association test, i.e. those individuals that occur in families with more than one genotype. QTDT assumes equal genotypes for MZ twins and includes non-typed MZ co-twins with IQ scores. Abbreviation: GE genotypic effect (increaser allele).