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. 1997 Jul 7;186(1):153–158. doi: 10.1084/jem.186.1.153

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Migrating T cells polarize the CCR2 receptor towards the chemoattractant gradient. (A–C) Time-lapse videomicroscopy analysis of migrating T lymphoblasts in response to MCP-1. Cells were allowed to adhere to 10 μg/ml rsICAM-1 on coverslips; MCP-1 was then deposited at one edge of the bottom of the well and cells allowed to migrate. Sequential time frames are shown. Polarized migrating lymphocytes show the phase-dark leading edge and the phase-bright uropod. (D) Parallel immunofluorescence studies show the CCR2 distribution of the migrating cells. Cells were photographed with a ×60 objective. Bar, 10 μm. The arrows indicate the direction of cell migration towards the chemokine source.