Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1997 Jul 7;186(1):71–81. doi: 10.1084/jem.186.1.71

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Anti–IFN-γ reverses the transferable suppression by cells from SEA-treated mice. (a) Mixed cultures of anergic and control CD4⁺ T cells were stimulated with APCs and PCCF in the presence and absence of the neutralizing XMG1.2 Ab. Live CD4⁺ cell recovery on day 4 is shown. (b) CD4⁺ effector cells generated in the presence of the XMG1.2 Ab develop the ability to secrete cytokines after antigenic restimulation. Effector cells were further purified on magnetic bead columns and restimulated with PCCF and APC. (c) 24-h supernatants were analyzed for cytokine content.

Anti–IFN-γ reverses the transferable suppression by cells from SEA-treated mice. (a) Mixed cultures of anergic and control CD4⁺ T cells were stimulated with APCs and PCCF in the presence and absence of the neutralizing XMG1.2 Ab. Live CD4⁺ cell recovery on day 4 is shown. (b) CD4⁺ effector cells generated in the presence of the XMG1.2 Ab develop the ability to secrete cytokines after antigenic restimulation. Effector cells were further purified on magnetic bead columns and restimulated with PCCF and APC. (c) 24-h supernatants were analyzed for cytokine content.