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. 1997 Jul 7;186(1):159–164. doi: 10.1084/jem.186.1.159

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Histologic analysis of CNS tissue after adoptive transfer of transfected T cells. The extent of demyelination was measured by immunocytochemical staining for PLP. (a) Representative section showing demyelination (arrow) in the spinal cord dorsal column of SWXJ control mouse adoptively transferred with normal splenocytes before EAE onset. (b) Representative section showing uniform distribution of PLP immunostaining in the spinal cord dorsal column of SWXJ mouse adoptively transferred before EAE onset with PLP 139–151-specific T cells transfected with the IL-2Prom→ IL-10cDNA construct. Closed Bar, 50 μm.