Table 2.
Effect of Bone Marrow Reconstitution After Irradiation
| Recipients | No. of mice | Irradiation | Donor BM | No. of mice/ total mice | Survival | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| rads | % | |||||||||
| −/− | 6 | 900 | +/+ | 0/6 | 0 | |||||
| −/− | 3 | 900 | Media | 0/3 | 0 | |||||
| −/− | 7 | None | +/+ | 0/7 | 0 | |||||
| −/− | 2 | None | Media | 0/2 | 0 | |||||
| +/+ | 12 | 900 | −/− | 10/12 | 83.3 | |||||
| +/+ | 13 | 900 | +/+ | 13/13 | 100 | |||||
| +/+ | 13 | 900 | Media | 0/13 | 0 |
Recipients were irradiated with 900 rads of γ irradiation 18 h before an intravenous injection of media or 1.5 × 106 donor BM. Recipients that were not irradiated were injected intravenously with 2.5 × 107 donor BM, as well as with an intraperitoneal injection of 2.0 × 107 donor splenic cells.