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. 1997 Aug 29;186(5):749–756. doi: 10.1084/jem.186.5.749

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C5a-dependent secretion of IL-6. The reverse passive Arthus reaction (IC) was allowed to proceed for 4 or 8 h in C5aR (−/−) mice (dotted bars) and their wild-type littermates (black bars). IL-6 content in the peritoneal fluid was determined by an IL-6–specific ELISA. Ab controls (Ab control) received Ab to chicken egg albumin i.p. without i.v. injection of chicken egg albumin. Mice treated with PBS i.p. followed by i.v. chicken egg albumin served as Ag controls (Ag control). Data are represented as mean ± SEM, n = 14–17 mice (4 h) and n = 7–9 mice (8 h). *P <0.004.