Table 2.
Life Span of Tumor Mice after Virus Infection
| Lineage | No. of mice | Life span* | P | |||
|---|---|---|---|---|---|---|
| RIP-Tag2 | 7 | 88 ± 8 | ||||
| <0.001 | ||||||
| RIP(GP × Tag2) | 9 | 137 ± 18 | ||||
| <0.005 | ||||||
| RIP(GP × Tag2) + AT | 4 | 168 ± 11 | ||||
| TCR RIP-Tag2 | 4 | 90 ± 17 | ||||
| <0.0001 | ||||||
| TCR RIP(GP × Tag2) | 4 | 183 ± 5 |
Mice were i.v. infected with LCMV the day after two consecutive blood glucose readings <5 mM which was at an age of 70–85 d. At necropsy, all mice had β-cell tumors.
Life span in days, mean ± SD. + AT (adoptive transfer): once hypoglycemia recurred in LCMV-infected, tumor-bearing mice, mice were adoptively transferred by i.v. injection of 5 × 107 spleen cells taken from C57BL/6 mice 8 d after i.v. LCMV infection.