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. 1997 Aug 18;186(4):589–600. doi: 10.1084/jem.186.4.589

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VAP-1 mediates binding of both L-selectin–positive and –negative lymphocytes to PLN HEV. (A) Expression of L-selectin on different lymphocyte populations. Total PBL, immunomagnetically separated L-selectin–positive and –negative subpopulations of PBL, and IL-2–activated T cells were stained for L-selectin expression and analyzed using FACScan^®. (B) L-selectin–negative T cells specifically recognize PLN HEVs. Five immunoblasts (black round cells, two pointed out by arrows) binding to a HEV (lilac basement membrane outlined by a dashed line) are shown in the micrograph. Bar, 20 μm. (C) Binding of these different lymphocytes to PLN HEVs after pretreatments with the indicated mAbs was analyzed.

VAP-1 mediates binding of both L-selectin–positive and –negative lymphocytes to PLN HEV. (A) Expression of L-selectin on different lymphocyte populations. Total PBL, immunomagnetically separated L-selectin–positive and –negative subpopulations of PBL, and IL-2–activated T cells were stained for L-selectin expression and analyzed using FACScan^®. (B) L-selectin–negative T cells specifically recognize PLN HEVs. Five immunoblasts (black round cells, two pointed out by arrows) binding to a HEV (lilac basement membrane outlined by a dashed line) are shown in the micrograph. Bar, 20 μm. (C) Binding of these different lymphocytes to PLN HEVs after pretreatments with the indicated mAbs was analyzed.