Figure 7.

Inhibitory effect of MV-infected DC and of DC supernatants in allogeneic MLR. (A and B) Supernatants from either mock-infected (□), day 2 Hallé- infected (▪), or LYS-1–infected (▨ ) DC were either untreated (A) or UV-irradiated (B) and added to cocultures of various numbers of uninfected DC and 2 × 10⁴ naive allogeneic CD4⁺ T cells. (C) Various numbers of either uninfected (□), Hallé-infected (♦), or LYS-1–infected (▪) DC were cocultivated for 6 d with 10⁴ uninfected DC and 2 × 10⁴ allogeneic CD4⁺ T cells. T cell proliferation was analyzed on day 6 of culture by thymidine uptake over the last 16 h of culture. The results are expressed as mean cpm ± SD of triplicate wells.