Table 1.

Recognition of CD8⁺ Influenza Epitopes by Freshly Isolated T Cells in the ELISPOT Assay for IFN-γ and Corresponding Peptide-specific T Cell Frequencies

Protein		Sequence		MHC class I restriction		No. of responders		No. of donors tested		Range of peptide-specific IFNγ SFCs (effector frequencies)/PBMC
M1 58–66		GILGFVFTL		HLA-A2.01		7		9		1/111,000–1/3,500
NP 380–388		ELRSRYWAI		HLA-B8		5		7		1/67,000–1/15,000
NP 265–273		ILRGSVAHK		HLA-A3		5		6		1/83,000–1/45,000
PB1 591–599		VSDGGPNLY		HLA-A1		2		4		1/100,000–1/91,000
MI 128–135		ASCMGLIY		HLA-B35		2		2		1/25,000–1/16,000
NP 383–391		SRYWAIRTR		HLA-B27.05		1		1		1/24,000