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. 1997 Sep 15;186(6):921–929. doi: 10.1084/jem.186.6.921

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Disruption of Ku70 confers radiation hypersensitivity and a deficiency in DNA DSB repair. (A) Radiation survival curves for the CFU-GM in the bone marrow of wild type (WT), Ku70⁻ ^/−, and Ku80⁻ ^/− mice (30, 32). (B) Deficiency in the repair of radiation-induced DSB in Ku70⁻ ^/− and Ku80⁻ ^/− cells (31). (Top) Rejoining of DNA DSB produced by 40 Gy x-ray. (Bottom) Induction of DNA DSB as a function of the radiation dose in wild-type, Ku70⁻ ^/−, and Ku80⁻ ^/− cells. •, wild type; ▴, Ku70⁻ ^/− ; and ▪, Ku80⁻ ^/− cells, respectively.

Disruption of Ku70 confers radiation hypersensitivity and a deficiency in DNA DSB repair. (A) Radiation survival curves for the CFU-GM in the bone marrow of wild type (WT), Ku70⁻ ^/−, and Ku80⁻ ^/− mice (30, 32). (B) Deficiency in the repair of radiation-induced DSB in Ku70⁻ ^/− and Ku80⁻ ^/− cells (31). (Top) Rejoining of DNA DSB produced by 40 Gy x-ray. (Bottom) Induction of DNA DSB as a function of the radiation dose in wild-type, Ku70⁻ ^/−, and Ku80⁻ ^/− cells. •, wild type; ▴, Ku70⁻ ^/− ; and ▪, Ku80⁻ ^/− cells, respectively.