Table 1.
Lymphoid Cellularity of Ku70−/− Mice
| Cell content (x 106) | ||||||
|---|---|---|---|---|---|---|
| Tissue and genotype | Total | B220+ | CD4+CD8+ | |||
| Thymus | ||||||
| wild type (n = 4) | 155 ± 42 | – | 104 ± 28 | |||
| Ku70−/− (n = 3) | 2.98 ± 0.91 | – | 0.6 ± 0.2 | |||
| Ku80−/− (n = 2) | 1.0 ± 0.5 | – | – | |||
| Bone marrow | ||||||
| wild type (n = 4) | 11.9 ± 3.3 | 5.5 ± 1.5 | – | |||
| Ku70−/− (n = 3) | 7.2 ± 2.9 | 1.1 ± 0.4 | – | |||
| Ku80−/− (n = 2) | 9.0 ± 3.0 | – | – | |||
| Spleen | ||||||
| wild type (n = 4) | 53 ± 20 | 29 ± 11 | – | |||
| Ku70−/− (n = 3) | 6.5 ± 1.3 | 0.4 ± 0.2 | – | |||
| Ku80−/− (n = 2) | 1.2 ± 0.5 | – | – | |||
Data shown are arithmetic means ± standard deviations from two to four individuals of each genotype analyzed at 4–6 wk of age. Cell numbers are shown per femur for bone marrow, and per whole organ for spleen and thymus.