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. 1997 Oct 6;186(7):1015–1026. doi: 10.1084/jem.186.7.1015

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Cell infiltration in 24-h CS ears was decreased by systemic treatment with anti-C5 mAb. Mice were immunized by painting with vehicle (a and b) or 5% PCl (c–f ) on day 0, and challenged on the ears with PCl on day 4. Then, saline (a, c, and e) or 1 mg anti-C5 mAb (b, d, and f ) was injected i.v. at 4 and 24 h before ear challenge. 5-μm sections of ears were obtained 24 h after Ag challenge, and were stained with hematoxylin and eosin. Magnification is 200 (a–d) or 1,000 (e and f ). Leukocyte infiltration in CS era responses (c) was decreased by anti-C5 mAb treatment (d). Intraepidermal abscesses of leukocytes were observed frequently in ears from immune and challenged mice treated with saline (c and e), but not in ears of mice treated with anti-C5 mAb (d and f ). Arrowheads in (c) denote intraepidermal abscess.